Mount Sinai Scientists Earn $12 Million to Elucidate New Causes of Food Allergies, Atopic Dermatitis

Mount Sinai researchers have received $12 million over five years from the National Institutes of Health to establish a center to elucidate new causes and contributing factors to food allergies and atopic dermatitis.

The Systems Biology of Early Atopy Analysis and Bioinformatics Center (SunBEAm) intends to develop a better understanding of the development of allergies. The center will apply systems biology to identify early risk markers for food allergies and atopic dermatitis (also known as eczema), as well as the biological pathways underlying these common conditions, through multi-data profiling and analysis Longitudinal omics from a multicenter prenatal cohort of 2,500 infants.

Food allergies and atopic dermatitis are complex diseases affecting approximately 8% and 20% of children, respectively. Food allergies are often preceded by atopic dermatitis, suggesting shared risk factors and overlapping pathobiology.

Individuals with food allergies are at daily risk of life-threatening conditions, including hives, difficulty breathing and/or anaphylaxis following ingestion of a food antigen to which they are sensitized. And for those with atopic dermatitis, they live with chronically inflamed skin that can cover a significant portion of their body.”


Supinda Bunyavanich, MD, MPH, MPhil, Mount Sinai Professor in Allergy and Systems Biology and the Center’s Principal Investigator

“This funding allows us to create a center that will have a significant impact on allergy research. A systems biology approach in which the biology of these common conditions is comprehensively studied at different levels can help identify new insights into allergy development. allergies, ultimately helping us improve the prevention, diagnosis and clinical management of food allergies and atopic dermatitis,” said Dr. Bunyavanich.

The SunBEAm Analysis and Bioinformatics Center includes researchers from Mount Sinai, Johns Hopkins, the University of North Carolina at Chapel Hill, Northwestern, and National Jewish Health. The SunBEAm birth cohort is a collaborative effort of researchers from 12 sites in the United States who are enrolling families for participation in this cohort study that follows parents and children from before birth through the child’s third birthday. SunBEAm is supported by the National Institutes of Allergy and Infectious Diseases, part of the National Institutes of Health (grant number 1UM1AI173380-01) and led by the Consortium for Food Allergy Research.

Source:

Mount Sinai Health System

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